7月20日高分子科学系列讲座预告

报告题目: Non-Classical Pathway for Protein Crystallization

报 告 人: 张发军　博士

单　  位: Universit？t Tübingen , Germany

报告时间: 2013年7月20日（星期六）上午9:30

报告地点: 应化所主楼四楼学术报告厅(410)

附：报告人简介及报告内容摘要

张发军博士，1997年毕业于天津南开大学化学系高分子物理专业。1998-2002在中国科学院长春应用化学研究所，师从何天白研究员攻读博士学位。并于2002年获得理学博士。2002-2003在比利时Catholic University of Louvain (UCL)博士后，2003-2005 Technische Universit？t Darmstadt, 德国洪堡奖学金，先后从事高分子结晶、共聚烯烃多分散性，高分子薄膜以及嵌段共聚物形态于结构的研究。从2005至今，在德国图宾根 (Tübingen) 大学物理系Schreiber教授研究组，博士后，项目组长，从事蛋白质物理，抗蛋白质吸附自组装膜，功能化纳米粒子与蛋白质的相互作用等研究。

当前研究兴趣：蛋白质、纳米粒子、胶体及胶束溶液相行为，小角散射(光，X射线及中子散射)在软物质物理的应用

Recent progresses in protein and colloid crystallization as well as biomineralization have shown non-classical features in the early stage of nucleation [1]. While the classical nucleation theory predicts that the solute molecules reversibly aggregate in the supersaturated solution and form nuclei with the exact density and structure of the crystals in the final stage, the non-classical pathway suggests an intermediate phase (clusters or dense liquid phase) exists in between the initial solution and the final crystalline state [1]. The free energy landscapes of the non-classical pathway show an additional free energy minimum corresponding to the intermediate phase. If the free energy of the intermediate phase is higher than that of the initial solution, it is unstable and the intermediate phase exists as mesoscopic clusters. If the free energy of the intermediate phase is lower than that of the initial solution, then the metastable phase can be a dense liquid phase [3]. Here we show that pre-assembled protein clusters formed via cation bridging can serve as a building block of crystallization. We also discuss the potential application of using trivalent metal ions for protein crystallization.

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