1. Yuping Shan and Hongda Wang*. The structure and function of cell membranes examined by atomic force microscopy and single-molecule force spectroscopy. Chemical Society Reviews, 2015, 44: 3617-3638.
2. Ye Wang, Jing Gao, Xingdong Guo, Ti Tong, Xiaoshan Shi, Lunyi Li, Miao Qi, Yajie Wang, Mingjun Cai, Junguang Jiang, Chenqi Xu*, Hongbin Ji*, Hongda Wang*, Regulation of EGFR nanocluster formation by ionic protein-lipid interaction. Cell Research, 2014, 24(8):959-976.
3. Yangang Pan, Fuxian Zhang, Liuyang Zhang, Shuheng Liu, Mingjun Cai, Yuping Shan*, Xianqiao Wang*, Hanzhong Wang*, Hongda Wang*. The process of wrapping virus revealed by a force tracing technique and simulations. Advanced Science, 2017, 4: 1600489.
4. Junling Chen, Tianzhou Liu, Jing Gao, Lan Gao, Lulu Zhou, Mingjun Cai, Yan Shi, Wenyong Xiong, Junguang Jiang, Ti Tong*, Hongda Wang*. Variation in carbohydrates between cancer and normal cell membranes revealed by super-resolution fluorescence imaging, Advanced Science, 2016, 3: 1600270.
5. Xian Hao, Nan Zhu, Tina Gschneidtner, Elvar Jonsson, Jingdong Zhang, Kasper Moth-Poulsen, Hongda Wang*, Kristian S. Thygesen, Karsten W. Jacobsen, Jens Ulstrup, Qijin Chi*. Direct measurement and modulation of single-molecule coordinative bonding forces in a transition metal complex. Nature Communications, 2013, 4: 2121.
6. Junguang Jiang, Xian Hao, Mingjun Cai, Yuping Shan, Xin Shang, Zhiyong Tang, Hongda Wang*. Localization of Na+-K+ ATPases in quasi-native cell membranes. Nano Letters, 2009, 9(12): 4489-4493.
7. Qiang Wu, Mingjun Cai, Jing Gao, Tan Zhao, Haijiao Xu, Qiuyan Yan, Yingying Jing, Yan Shi, Chuanqing Kang, Yi Liu, Feng Liang, Junling Chen*, Hongda Wang*, Developing substrate-based small molecule fluorescent probes for super-resolution fluorescent imaging of various membrane transporters, Nanoscale Horizons, 2020, 5(3): 523-529.
8. Yangang Pan, Yuebin Zhang, Pianchou Gongpan, Qingrong Zhang, Siteng Huang, Bin Wang, BingqianXu, YupingShan*, Wenyong Xiong*, Guohui Li*, Hongda Wang*, Single glucose molecule transport process revealed by force tracing and molecular dynamics simulations, Nanoscale Horizons, 2018, 3(5):517-524.
9. Qiuyan Yan, Yanting Lu, Lulu Zhou, Junling Chen, Haijiao Xu, Mingjun Cai, Yan Shi, Junguang Jiang, Wenyong Xiong*, Jing Gao*, Hongda Wang*, Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging, Proceedings of the National Academy of Sciences, 2018, 115(27):7033-7038.
10. Hongda Wang, Linda Obenauer-Kutner, Mei Lin, Yunping Huang, Michael Grace, Stuart Lindsay*. Imaging glycosylation. Journal of the American Chemical Society, 2008, 130(26): 8154-8155.
1. Membrane Biophysics: New Insights and Methods, Hongda Wang and Guohui Li, Editors. Springer Singapore, 2018, Singapore.
2. Pharmaceutical Nanotechnology: Basic Protocols, Weissig Volkmar, and Elbayoumi Tamer, Editors. Springer New York, 2019, New York, NY. Chapter 22 Atomic Force Microscopy for Cell Membrane Investigation (P361-372). Mingjun Cai, Hongda Wang.
3. 庞代文、蒋兴宇、黄卫华主编,纳米科学与技术丛书《纳米生物检测》,科学出版社,2014,北京。第8章,利用原子力显微镜和识别技术研究细胞膜结构(P183-216),王宏达,蔡明军。
1.超分辨荧光显微镜搭建及原子力显微镜与超分辨荧光显微镜连用系统建立
王宏达研究员课题组致力于超分辨荧光显微镜的搭建工作,已经取得重大成果,可以根据不同的实验要求,添加各种光源,拓展了超分辨荧光显微镜的应用空间,并利用自我研发的超分辨荧光显微镜和数据处理体系发表多篇高档次论文(Adv. Sci.、Nanoscale Horiz.等)。近期新开发的原子力显微镜与超分辨荧光显微镜连用系统结合了二者的优势,可以实现样品的原位及实时成像,并完善了后期数据处理方法,取得的成果发表在Nanoscale上。
2.新型细胞膜模型以及囊泡有序转运动态模型的确立
王宏达研究员课题组利用多种单分子技术证明了生物膜内外蛋白质分布的不对称性,进而提出了新的红细胞膜模型(“半镶嵌模型”)、组织细胞膜模型(“蛋白质层-脂质-蛋白岛”模型)以及囊泡有序转运动态模型(“膜不对称性决定有序的细胞器转运”)。证明了细胞膜、转运囊泡膜以及高尔基体膜的不对称性是其行使生物功能的重要结构依据。这些研究成果得到了国内外研究学者的认可,并发表在Chem. Soc. Rev.、PNAS、Nanoscale Horiz.、AC等高水平论文中。
3.基于超分辨荧光显微镜的小分子探针标记方法的确立
王宏达研究员课题组潜心研发的小分子探针标记方法利用尺寸较小且单价标记的探针,如适配体、多肽和抑制剂等探针,实现了对细胞膜上一些糖分子、膜蛋白的精确识别。这种方法可以避免传统探针(抗体,凝集素)的很多缺陷,如尺寸相对较大、多价态、空间位阻大、交联现象明显等。小分子探针标记方法提高了探针分子的定位精度,为超分辨技术开拓了一个新思路。该方法的研究成果多次被SCI高水平杂志收录,如Adv. Sci.、Nanoscale Horiz.、Nanoscale、AC等。