1. Yufei Sun, Guifang Feng, Zheng, Yan, Shu Liu*, Zhang, Yan, Zifeng Pi, Fengrui Song, Zhiqiang Liu*. Putative multiple reaction monitoring strategy for the comparative pharmacokinetics of postoral administration Renshen-Yuanzhi compatibility through liquid chromatography-tandem mass spectrometry. J Ginseng Res., 2020, 44(1): 105-114.
2. Zhang, Lin, Tengfei Xu, Zifeng Pi*, Zheng, Meizhu, Fengrui Song, Zhiqiang Liu*. Effects of the ambient fine particulate matter (PM2,5) exposure on urinary metabolic profiles in rats using UPLC-Q-TOF-MS. Chinese Chem. Lett., 2019, 30(1): 90-94.
3. Zheng Yan, Shu Liu*, Junpeng Xing, Zhong Zheng, Zifeng Pi, Fengrui Song, Zhiqiang Liu*. Equivalently Quantitative Ion Strategy with Quaternary Ammonium Cation Derivatization for Highly Sensitive Quantification of Lanostane-Type Triterpene Acids without Standards by Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS). Anal. Chem., 2018, 90(23): 13946-13952.
4. Xiaoyu Zhuang, Bing Zhao, Shu Liu, Fengrui Song, Fengchao Cui*, Zhiqiang Liu*, Yunqi Li. Noncovalent Interactions between Superoxide Dismutase and Flavonoids Studied by Native Mass Spectrometry Combined with Molecular Simulations. Anal. Chem., 2016, 88(23): 11720-11726.
5. Xiaoyu Zhuang, Shu Liu, Ruixing Zhang, Fengrui Song*, Zhiqiang Liu*, Shuying Liu. Identification of Unfolding and Dissociation Pathways of Superoxide Dismutase in the Gas Phase by Ion-Mobility Separation and Tandem Mass Spectrometry. Anal. Chem., 2014, 86(23): 11599-11605.
6. Guifang Feng, Yan Zheng, Yufei Sun, Shu Liu*, Zifeng Pi, Fengrui Song, Zhiqiang Liu*. A targeted strategy for analyzing untargeted mass spectral data to identify lanostane-type triterpene acids in Poria cocos by integrating a scientific information system and liquid chromatography-tandem mass spectrometry combined with ion mobility spectrometry. Anal. Chim. Acta, 2018, 1033: 87-99.
7. Tengfei Xu, Zifeng Pi*, Fengrui Song, Shu Liu, Zhiqiang Liu*. Benzophenone used as the photochemical reagent for pinpointing C=C locations in unsaturated lipids through shotgun and liquid chromatography-mass spectrometry approaches. Anal. Chim. Acta, 2018, 1028: 32-44.
8. Chen Xu, Shu Liu*, Zhiqiang Liu*, Fengrui Song, Shuying Liu. Superoxide generated by pyrogallol reduces highly water-soluble tetrazolium salt to produce a soluble formazan: A simple assay for measuring superoxide anion radical scavenging activities of biological and abiological samples. Anal. Chim. Acta, 2013, 793(1): 53-60.
9. Guifang Feng, Yufei Sun, Shu Liu*, Fengrui Song, Zifeng Pi, Zhiqiang Liu*. Stepwise targeted matching strategy from in vitro to in vivo based on ultra-high performance liquid chromatography tandem mass spectrometry technology to quickly identify and screen pharmacodynamic constituents. Talanta, 2019, 194: 619-626.
10. Yao Qi, Shizhe Li, Zifeng Pi, Fengrui Song, Lin, Na, Shu Liu*, Zhiqiang Liu*. Chemical profiling of Wu-tou decoction by UPLC-Q-TOF-MS. Talanta, 2014, 118(1): 21-29. SCI IF：4.91
1. 发明专利：一种筛选超氧阴离子清除剂的方法
专利号：ZL 201210341636.3
发明(设计)人：刘志强. 徐晨. 刘舒. 邢俊鹏. 宋凤瑞. 郑重. 刘淑莹.
授权公告日：2015-11-18
2. 发明专利：一种测定超氧化物歧化酶活性的方法
专利号：ZL 201210341599.6
发明(设计)人：刘志强. 徐晨. 刘舒. 邢俊鹏. 宋凤瑞. 郑重. 刘淑莹.
授权公告日：2015-11-18
3. 发明专利：一种3-表酯蟾毒配基的制备方法
专利号：ZL 201010584074.6
发明(设计)人：刘志强. 韩天娇. 宋凤瑞. 郑重. 邢俊鹏. 刘淑莹.
授权公告日：2014-05-21
4. 发明专利：一种人参皂苷饮品的制备方法
专利号：ZL 201510881658.2
发明(设计)人：郑重. 宋凤瑞. 刘舒. 刘志强. 李川.
授权公告日：2018-05-15
5. 发明专利：一种中药组合物、其制备方法及中药制剂
专利号：ZL 201510408426.5
发明(设计)人：皮子凤. 刘志强. 宋凤瑞. 张艳.
授权公告日：2018-06-01
1、中药药效物质基础研究新方法开发及应用
针对中药药效物质基础研究的关键技术瓶颈问题，基于中药作用特点，创新性地提出了“体外-体内”化学物质组逐层递进关联分析策略，超滤-质谱联用分析方法、微透析-质谱联用分析方法及靶向网略药理学方法，并将上述方法成功应用于中药新药研发和中药大品种二次开发，实现了中药及其复方体外-体内化学轮廓的快速剖析、中药活性成分的高通量筛选及中药体内过程和作用机制的集成分析。自主研发的2个中药新药已获得临床批件并转化。
2、功能化探针电喷雾电离源研制
通过设计加工探针尖端高压电离装置和气体离子热辅助气聚集装置，结合取样探针功能化修饰，成功开发了一种功能化探针电喷雾电离源。该离子源不仅可以进行原位、活体取样分析，并且可以进行单细胞分析，相关成果已经申请实用新型专利和发明专利。
人才队伍
